Pdf benzo a pyrene at human blood equivalent level. A benzopyrene is an organic compound with the formula c 20 h 12. In the following, either the cas name benzo apyrene or the abbreviation bap is used for the substance benzodefchrysene. Benzo apyrene standard benzo apyrene standard with a purity of 99. Benzo apyrene is found in nature from the eruption of volcanoes and forest fires.
The substance with the formula c 20 h 12 is one of the benzopyrenes, formed by a benzene ring fused to pyrene. C20h12 a fivering aromatic hydrocarbon found in coal tar, in cigarette smoke, and as a product of incomplete combustion. Its analysis in water involves extraction of 500 ml of sample using solid phase extraction or liquidliquid partition, concentration of the extracts to 0. Monoclonal antibodies to a benzoapyrene diolepoxide. This article calls benzo apyrene diol the ultimate carcinogen is that a fair classification. Pyrene is a parent class of polycyclic aromatic hydrocarbons containing four fused rings. Relevant identified uses of the substance or mixture and uses advised against identified uses laboratory reagent. The extraction was performed on nine brands of moist snuff samples that are commercially available and were purchased from the market in january 2018. Monoclonal antibodies to a benzo apyrene diolepoxide modified protein regina m. This information is distributed solely for the purpose agency determination or policy. Benzoapyrene is found in nature from the eruption of volcanoes and forest fires. Incompatible with strong oxidizing agents including various electrophiles, peroxides, nitrogen oxides and sulfur oxides. Chemical properties of benzoapyrene cas 50328 download as pdf file download as excel file download as 2d mole file predict properties.
In this dossier, benzodefchrysene will be identified as svhc according to the criteria of article 57 a e. They belong to the chemical class of polycyclic aromatic hydrocarbons. Iris file for information on longterm toxic effects other than carcinogenicity. Benzo apyrene, benzo b fluoranthene, benzokfluoranthene and dibenzo a,hanthracene ranged between 1. Us epa, oswer, office of resource conservation and recovery subject. It is also found in emissions from combustion of oil, coal, wood and garbage. Once benzo apyrene has entered the small intestine, it is solubilized by bile salts and absorbed ermala et. Files are available under licenses specified on their description page.
Pyrene is a potential metabolite of bapdegradation kweon et al. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Information on benzo apyrene bap, an indicator species for polycyclic aromatic hydrocarbons pahs, for use in responding to chemical incidents. Oxidized by ozone, chromic acid and chlorinating agents. Benzoepyrene appeared to reduce the incidence of carcinomas from 65% benzo apyrene alone to 40% benzo apyrene plus benzoepyrene. Benzo apyrene bap is the most potent carcinogenic substance among the pahs and as long as its relative contribution to total pah is relatively constant in foods, bap concentration is a good indicator of the total carcinogenic potency of a mixture alexander et al. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Benzo apyrene exposure induced multiple alterations in dna methylation and in mrna expressions of dna methyltransferases and ten11 translocation proteins. At the june 1992 crave work group meeting, a revised risk estimate for benzo apyrene was verified see additional comments for oral exposure.
Interestingly, most of the partial degraders accept pyrene as growth substrate. The hazard fields include special hazard alerts air and water reactions, fire hazards, health hazards, a reactivity profile, and details about reactive groups assignments and potentially incompatible absorbents. Benzoapyrene bap is the most potent carcinogenic substance among the pahs, and as long as its relative contribution to total pah is relatively constant in foods, bap concentration is a good indicator of the total carcinogenic potency of a pah mixture alexander et al. All structured data from the file and property namespaces is available under the creative commons cc0 license. The absorption of benzo apyrene from the gastrointestinal tract of mice and cats is enhanced when it is solubilized in vehicles possessing both lipophilic and hydrophilic properties ekwall et al. Benzo apyrene pah, a polycyclic aromatic hydrocarbon pollutant, is used as a chemical carcinogen in experimental models of cancer. For the cigarettes, mean values of bap ranged from 3. Incidence of nonneoplastic and neoplastic lesions in female b6c3f 1 mice fed benzo apyrene in the diet for up to 2 years d56 table d. Extraction from moist snuff with artificial saliva of. Formation and persistence of benzoapyrene metabolitedna. However, the incidence of sarcoma in tracheal and peritracheal explants was enhanced two to threefold by benzoepyrene given with benzo apyrene compared with benzo apyrene alone.
Please see the following for information about the library and its accompanying search program. Benzoapyrene undergoes photooxidation after irradiation in indoor sunlight or by fluorescent light in organic solvents. The present study evaluated in vitro extractability of various polycyclic aromatic hydrocarbons pahs from moist snuff, when the extracting agent was water or artificial saliva. However, some human studies report associations between particular health endpoints and internal measures of exposure, such as benzo apyrene deoxyribonucleic acid dna adducts, or external measures of benzo apyrene exposure. Review of benzoapyrene in support of summary information on the integrated risk information system iris august 20. Benzoapyrene is on the priority pollutant list published by the u. Benzoapyrene is an important commercial chemical used to make dyes. They are formed during the combustion of carbonaceous material at high temperatures 1. Gcmsms analysis of benzoapyrene with agilent 7890 and. This structure is also available as a 2d mol file or as a computed 3d sd file the 3d structure may be viewed using java or javascript. Benzog,h,iperylene fact sheet us epa archive document.
University of california, san francisco library ucsf. Benzo apyrene is on the priority pollutant list published by the u. Benzoapyrenein iarc monograph volume 32 iarc, 1983 no evaluation was made of studies of carcinogenicity in experimental animals published since 1972, but it was concluded that there is sufficient evidence for the carcinogenicity of benzo a pyrene in experimental animals. The oral slope factor was adjusted by a combined age sensitivity factor of 1. Benzoalphapyrene article about benzoalphapyrene by. Public health goal for benzoapyrene in drinking water. Most of the pahs with low vapour pressure in the air are adsorbed on particles. Benzoapyrene, or bap, is one of a group of compounds called polycyclic aromatic hydrocarbons pahs. Degradation of benzoapyrene by bacterial isolates from. Rapid analysis of benzoapyrene in water at ppt level. Structurally speaking, the colorless isomers of benzopyrene are pentacyclic hydrocarbons and are fusion products of pyrene and a phenylene group. The in vivo formation of bp metabolitedna adducts has been characterized in a variety of target. Benzoapyrene bp and other polycyclic aromatic hydrocarbons pah are ubiquitous environmental pollutants and are suspected to be carcinogenic in man. Pyrene is an ortho and perifused polycyclic arene consisting of four fused benzene rings, resulting in a flat aromatic system.
The information in cameo chemicals comes from a variety of data sources. Where can benzoapyrene be found and how is it used. This page was last edited on 14 december 2015, at 14. They are not produced or used commercially but are very commonly found since they are formed as a result of incomplete combustion of organic materials. Benzo apyrene page 3 of toxicological overview introduction pahs are a large group of compounds consisting of hydrocarbons containing two or more benzene rings fused together or to other hydrocarbon rings. Biotransformation of benzo apyrene analysis, metabolism and adduct formation in rats and ahr knockout mice dissertation for the degree of ph. Benzog,h,iperylene fact sheet us epa archive document author. Bap is a polycyclic aromatic hydrocarbon and a component of air pollution. Gcmsms analysis of benzoapyrene with agilent 7890 and 240 june 17, 2011 confidentiality label 1 linearity and precision eimsms. They have a relatively low solubility in water, but are highly lipophilic.
Santella cancer centerinstitute of cancer research and school of public health, division of environmental sciences, columbia university health sciences. Benzoapyrene was also reported in cooking oils, butter, fats, margarine, coffee, tea, and some cereals, fruits and vegetables. For the remaining 60%, the molar growth yields indicate the degradation to be partial. Where can benzo apyrene be found and how is it used. Two isomeric species of benzopyrene are benzopyrene and the less common benzopyrene. The ubiquitous compound can be found in coal tar, tobacco smoke and many foods, especially grilled meats. We evaluated the relationship between residential carpet dust pah concentrations benzaanthracene, benzo apyrene, benzobfluoranthene, benzokfluoranthene, chrysene, dibenza,hanthracene, and indeno1,2,3c,dpyrene, and their sum and risk of nhl 676 cases, 511. Information from its description page there is shown below. We evaluated the benzo apyrene bap content in the smoke from 35 brands of canadian cigarettes and 5 brands of canadian tobaccos for rollyourown cigarettes. All mass spectra in this site plus many more are available from the nistepanih mass spectral library. This section provides information on three aspects of the carcinogenic risk assessment for. Determination of benzoapyrene levels in smoked and oil.
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