Oel fastrac is a convenient and affordable way for pharmaceutical, biotechnology, medical device and other life science companies. Levodopa and benserazide drug information, professional. Msds contains all of the information required by those regulations. Identification product name pyridoxine hydrochloride cat no. This protein is responsible for decarboxylating ldopa to dopamine, 5hydroxytryptophan to serotonin, and tryptophan to tryptamine. Suppliers list, emailrfq form, molecular structure, weight, formula, iupac, synonyms for benserazide hydrochloride cas no. Accidental release measures contain spill and collect, as appropriate. Hydrochloric acid, 37% ww 7647010 ld50 oral rat 700 mgkg. Risks of explosion of the product in presence of static discharge. Hydrogen chloride hcl hazardous decomposition products section 10. Popaedriatic dosage 20kg not recommended in this age group. Benserazide hcl, 14919778, benzerazide hydrochloride, dlserine 2, ccris 5092, ro 44602001. An aromaticlaminoacid decarboxylase inhibitor dopa decarboxylase inhibitor that does not enter the central nervous system, it is used as its hydrochloride salt as an adjunct to levodopa in the treatment of. The ideal choice for forensic and toxicology testing.
Apr 23, 20 benserazide is degradated by hydrolysis to ro 041419, which can bind one molecule of benserazide to the dimer ro 081580. Benserazide hydrochloride european pharmacopoeia ep. The chromatographic procedure may be carried out using. In a reaction solvent selected from water, ethanol, isopropanol, and glycol dimethyl ether, in the presence of hydrogen and a catalyst, serine hydrazide hydrochloride and 2,3,4trihydroxybenzaldehyde are subjected to a reaction to obtain benserazide hydrochloride.
A provided synthetic method for an intermediate of benserazide hydrochloride comprises the following steps. As our channel brand, vwr offers an integrated, seamless purchasing experience that is optimized for the way our. Airgas usa, llc and its affiliates 259 north radnorchester road suite 100 radnor, pa 190875283. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. Eye contact skin contact inhalation ingestion immediately flush eyes with running water for at least 15 minutes, keeping eyelids open. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Hydrogen chloride gas forms at temperatures above 2732f. These combinations are also used for the treatment of restless legs syndrome. Technical details about benserazide hydrochloride, learn more about the structure, uses, toxicity, action, side effects and more benserazide hydrochloride also known as. Benserazide hydrochloride c10h16cln3o5 cid 26964 structure, chemical names, physical and chemical properties, classification, patents, literature. Potential health effects do not induce vomiting because of danger of aspirating liquid into lungs. The company operates in more than 30 countries and delivers an extensive portfolio of products and services.
Msdssds database search a safety data sheet sds,material safety data sheet msds, or product safety data sheet psds is a document that lists information relating to occupational safety and health for the use of various substances and products. The progressive degeneration of these neurons that occurs in parkinsons. Dopa decarboxylasebenserazide is commonly used for parkinsons disease in combination with ldopa as a peripheral aromatic lamino acid decarboxylase aadc inhibitor. Airgas usa, llc and its affiliates 259 north radnorchester road suite 100 radnor, pa. Toxicological information eye irritation hazardous in case of eye contact irritant.
Before using benserazide hydrochloride, inform your doctor about your current list of medications, over the counter products e. Benserazide hydrochloride safety data sheet section 2. Benserazide hydrochloride european pharmacopoeia ep reference standard synonym. Benserazide hydrochloride 14919778 tokyo chemical industry co. Empirical formula hill notation c 10 h 15 n 3 o 5 hcl. Benserazide hydrochloride is a peripherallyacting aromatic lamino acid decarboxylase aaad or dopa decarboxylase inhibitortarget. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. High quality cas 14919778 benserazide hydrochloride benserazide hcl quick details cas no 14919778 other names. It is used in the management of parkinsons disease in combination with ldopa as cobeneldopa, under the brand names madopar in the uk and prolopa in canada, both made by roche. Thermal oxidative decomposition produces toxic chlorine fumes and explosive hydrogen gas. Levodopanormal motor function depends on the synthesis and release of dopamine by neurons projecting from substantia nigra to corpus striatum. Dlserine 22,3,4trihydroxybenzyl hydrazide hydrochloride cas number 14919778. Benserazide is a carbohydrazide that results from the formal condensation of the carboxy group of dlserine with the primary amino group of 4hydrazinylmethylbenzene1,2,3triol.
If you accept without changing your settings, we assume that you are happy to receive all cookies on the lgc website. Explosion hazards in presence of various substances. Benserazide hydrochloride can be analyzed by this reverse phase rp hplc method with simple conditions. We use cookies to ensure that we give you the best experience of our website. Benserazide hydrochloride 14919778 buy and find out price and availability, msds, properties of tcis high quality specialty chemicals. However, we make no warranty of merchantability or any other warranty, express or implied, w ith respect to such information, and we assume no liability resulting from its use. Extreme high moderate low section 1 chemical product and company identification product name benserazide. An aromaticlaminoacid decarboxylase inhibitor dopa decarboxylase inhibitor that does not enter the central nervous system, it is used as its hydrochloride.
Benserazide definition of benserazide by medical dictionary. Copying of any msds displayed is permitted for personal use only and otherwise is not permitted. Singledose study of slow release preparation of levodopa and benserazide madopar hbs. Toxic by inhalation, in contact w ith skin and if swallowed.
High quality reference standards for the most reliable pharmaceutical testing. High quality cas 14919778 benserazide hydrochloride. Levodopa can be metabolised to dopamine on either side of the bloodbrain barrier and so it is generally administered with a dopa decarboxylase inhibitor like carbidopa to prevent metabolism until after it has crossed the bloodbrain barrier. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy. Material safety data sheet of benserazide hydrochloride. It is our responsibility to meet your needs and efficiently serve you. Neonatal dosage 3kg not recommended in his age group. Safety data sheet northwest missouri state university. Benserazide hydrochloride china ningbo nfc chemical. The specifications for content of specific degradation products of benserazide hydrochloride are limited to 3.
Page 3 of 7 msds t acetonitrile flames and sparks, of heat, of oxidizing materials. The mobile phase contains an acetonitrile mecn, water, and phosphoric acid. Benserazide hydrochloride is a medicine available in a number of countries worldwide. Burning sodium perchlorate may produce chlorine, chlorine dioxide, hydrogen chloride, and oxides of nitrogen as well as mixtures with any other compounds involved in the combustion. Identification of the substancemixture and of the companyundertaking product name. Animal pharmaceuticals, pharmaceutical raw materials. Methods and material for containment and cleaning up. Safety data sheet creation date 15dec2011 revision date 04mar2019 revision number 5 1.
Buy benserazide hydrochloride online at lgc standards. Benserazide is a carbohydrazide that results from the formal condensation of the carboxy group of dlserine with the primary amino group of 4 hydrazinylmethylbenzene1,2,3triol. Dl serine 2 2,3,4trihydroxybenzylhydrazide hydrochloride. A list of us medications equivalent to benserazide hydrochloride is available on the website. When given with levodopa, benserazide produces higher brain concentrations of dopamine with lower doses of levodopa, thus lessening the side effects seen with higher doses. Material safety data sheet perchloric acid, 70% msds section 1.
The invention provides a onestep method for quickly preparing benserazide hydrochloride. Pharmaceutical quality of seven generic levodopabenserazide. Cas registry number chemical abstracts service 0000322350. Stability and reactivity low order of acute toxicity. Gain reliable data with our benserazide hydrochloride reference standards.
Levodopa is a prodrug of dopamine that is administered to patients with parkinsons due to its ability to cross the bloodbrain barrier. Msdssds database search safety data sheets library chemsrc. Benserazidehcl ro 44602 is a small molecule inhibitor of extracerebral ddc aromatic laminoacid decarboxylase, also known as dopa decarboxylase. Risks of explosion of the product in presence of mechanical impact.
Transfer to a chemical waste container for disposal in accordance with local regulations. Hcl ro 44602 statement of hazardous nature considered a hazardous substance according to osha 29 cfr 1910. For research use only, not for human or veterinary use. Benserazide hydrochloride drug information, uses, side. For massspec ms compatible applications the phosphoric acid needs to be replaced with formic acid. Safety data sheet ghs product identifier other means of identification emergency telephone number with hours of operation section 1. Section 16 additional information msds creation date. Costentin, in presynaptic receptors and neuronal transporters, 1991. China benserazide hydrochloride manufacturers, suppliers. Data sources include ibm watson micromedex updated 10 apr 2020, cerner multum updated 6 apr 2020, wolters kluwer updated. When heated to decomposition, emits toxic hydrogen chloride fumes and will react with water or steam to produce heat and toxic and corrosive fumes. It is used in the management of parkinsons disease in combination with ldopa levodopa as cobeneldopa ban, under the brand names prolopa in canada and madopar in the uk, both made by roche. Benserazide hydrochloride einecs no 14919778 place of origin. Ensure that medical personnel are aware of the materials involved and take precautions to protect themselves.
Chemical product and company identification product name. Affygility solutions ehs compliance management software. Material safety data sheet inhibited hydrochloric acid 15%. In particular the msds s displayed cannot be copied for the purpose of sale or licence or for inclusion as part of a collection of msds without the express written consent of acohs pty ltd. Benserazide hydrochloride european pharmacopoeia 6.
Bp2677100 casno 58560 synonyms 3hydroxy4,5dimethylolalphapic. Sigmaaldrich offers a number of benserazide hydrochloride products. Some health conditions may make you more susceptible to the sideeffects of the drug. These are common byproducts of combustion and are likely to be serious health concern. If you can not locate your required intermediate for benserazide hydrochloride on this page, you may send us a sourcing request for the specific benserazide hydrochloride intermediate you are looking for along with its cas no, and the intermediate name and we shall come back to you promptly with more. Benserazide hcl is a peripherallyacting aromatic lamino acid decarboxylase aaad or dopa decarboxylase inhibitor.
China benserazide hydrochloride, benserazide hydrochloride. Since 2002, affygility solutions has been providing potent compound safety, occupational toxicology and industrial hygiene services to biotechnology, pharmaceutical and medical device companies throughout the world. Vitamin b6 hydrochloride recommended use laboratory chemicals. Each madopar hbs 125 capsule 100 mg levodopa and 28. Other companies are charging thousands of dollars to set up accounts and give you access to their msds online database. Intermediates of benserazide hydrochloride, manufacturer. Benserazide also called serazide or ro 44602 is a peripherally acting aromatic lamino acid decarboxylase or dopa decarboxylase inhibitor, which is unable to cross the bloodbrain barrier indications. The solubility of benserazide hydrochloride in these solvents is approximately 16 and 20 mgml, respectively. Type the keywords youre interested in such as benserazide hydrochloride and make direct contact with any desirable suppliers manufacturers wholesalers for more important details or find similar choices that are 14919778, cheap benserazide hcl, discount pharmaceutical chemicals. Every single member from our large efficiency revenue team values customers wants and company communication for benserazide hydrochloride, 4hydroxy3methoxybenzylamine hydrochloride, 3hydroxybutyric acid sodium, 62765, sincerely hope we are growing up together with our customers all over the world. Global benserazide hydrochloride cas 14919778 manufacturing, technology, market landscape and distribution policy report 2016 research and markets november 30, 2016 02.
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